3‐O‐methyldopa administration does not alter fluorodopa transport into the brain
Identifieur interne : 004619 ( Main/Exploration ); précédent : 004618; suivant : 0046203‐O‐methyldopa administration does not alter fluorodopa transport into the brain
Auteurs : Mark Guttman [Canada] ; Gabriel Léger [Canada] ; Jesse M. Cedarbaum [États-Unis] ; Avinoam Reches [Israël] ; William Woodward [États-Unis] ; Alan Evans [Canada] ; Mirko Diksic [Canada] ; Mirko Gjedde [Canada]Source :
- Annals of Neurology [ 0364-5134 ] ; 1992-06.
Abstract
To determine if 3‐O‐methyldopa (3OMd) significantly inhibits the transport of 6‐{18F} fluorodopa (6‐FD) into the brain at the concentration normally encountered during L‐dopa administration, we performed 6‐FD studies with positron emission tomography in cynomolgus monkeys in the presence and absence of 3OMd. Infusion of 3OMd was designed to produce plasma concentrations equivalent to those seen in patients on chronic L‐dopa therapy. Plasma 3OMd levels of 39 ± μM did not alter the blood–brain transfer rate of 6‐FD. 6‐FD positron emission tomographic studies in parkinsonian patients will therefore not be altered by 3OMd present in the blood in those patients taking L‐dopa preparations. These results do not support the hypothesis that transport of L‐dopa into the brain is inhibited by 3OMd to cause the declining response seen in patients with advanced Parkinson's disease.
Url:
DOI: 10.1002/ana.410310611
Affiliations:
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Cedarbaum</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Neuroscience, Cornell University Medical College, Burke Rehabilitation Center, White Plains, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Reches, Avinoam" sort="Reches, Avinoam" uniqKey="Reches A" first="Avinoam" last="Reches">Avinoam Reches</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Woodward, William" sort="Woodward, William" uniqKey="Woodward W" first="William" last="Woodward">William Woodward</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, The Oregon Health Sciences University, Portland, OR</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Evans, Alan" sort="Evans, Alan" uniqKey="Evans A" first="Alan" last="Evans">Alan Evans</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Monteral, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Diksic, Mirko" sort="Diksic, Mirko" uniqKey="Diksic M" first="Mirko" last="Diksic">Mirko Diksic</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Monteral, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Gjedde, Mirko" sort="Gjedde, Mirko" uniqKey="Gjedde M" first="Mirko" last="Gjedde">Mirko Gjedde</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Monteral, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="3"><country>Canada</country><wicri:regionArea>Montreal Neurological Institute, 3801 University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1992-06">1992-06</date><biblScope unit="volume">31</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="638">638</biblScope><biblScope unit="page" to="643">643</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">A8F64B23877FE2A9B7693E4C2EA505D64415A34F</idno><idno type="DOI">10.1002/ana.410310611</idno><idno type="ArticleID">ANA410310611</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine if 3‐O‐methyldopa (3OMd) significantly inhibits the transport of 6‐{18F} fluorodopa (6‐FD) into the brain at the concentration normally encountered during L‐dopa administration, we performed 6‐FD studies with positron emission tomography in cynomolgus monkeys in the presence and absence of 3OMd. Infusion of 3OMd was designed to produce plasma concentrations equivalent to those seen in patients on chronic L‐dopa therapy. Plasma 3OMd levels of 39 ± μM did not alter the blood–brain transfer rate of 6‐FD. 6‐FD positron emission tomographic studies in parkinsonian patients will therefore not be altered by 3OMd present in the blood in those patients taking L‐dopa preparations. These results do not support the hypothesis that transport of L‐dopa into the brain is inhibited by 3OMd to cause the declining response seen in patients with advanced Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Israël</li><li>États-Unis</li></country><region><li>Oregon</li><li>Québec</li><li>État de New York</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name></region><name sortKey="Diksic, Mirko" sort="Diksic, Mirko" uniqKey="Diksic M" first="Mirko" last="Diksic">Mirko Diksic</name><name sortKey="Evans, Alan" sort="Evans, Alan" uniqKey="Evans A" first="Alan" last="Evans">Alan Evans</name><name sortKey="Gjedde, Mirko" sort="Gjedde, Mirko" uniqKey="Gjedde M" first="Mirko" last="Gjedde">Mirko Gjedde</name><name sortKey="Gjedde, Mirko" sort="Gjedde, Mirko" uniqKey="Gjedde M" first="Mirko" last="Gjedde">Mirko Gjedde</name><name sortKey="Leger, Gabriel" sort="Leger, Gabriel" uniqKey="Leger G" first="Gabriel" last="Léger">Gabriel Léger</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Cedarbaum, Jesse M" sort="Cedarbaum, Jesse M" uniqKey="Cedarbaum J" first="Jesse M." last="Cedarbaum">Jesse M. Cedarbaum</name></region><name sortKey="Woodward, William" sort="Woodward, William" uniqKey="Woodward W" first="William" last="Woodward">William Woodward</name></country><country name="Israël"><noRegion><name sortKey="Reches, Avinoam" sort="Reches, Avinoam" uniqKey="Reches A" first="Avinoam" last="Reches">Avinoam Reches</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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